Recommanded Product: 128071-75-0In 2019 ,《Functionalization of 4-bromobenzo[c][2,7]naphthyridine via regioselective direct ring metalation. A novel approach to analogs of pyridoacridine alkaloids》 appeared in Beilstein Journal of Organic Chemistry. The author of the article were Melzer, Benedikt C.; Plodek, Alois; Bracher, Franz. The article conveys some information:
Readily available 4-bromobenzo[c][2,7]naphthyridine undergoes regioselective direct ring metalation at C-5 with TMPMgCl·LiCl at -40°. Quenching with various electrophiles gives a broad range of 5-substituted products, which are building blocks for the synthesis of heterocyclic natural products and analogs thereof. In combination with a Parham-type cyclization a novel approach to pyrido[4,3,2-mn]acridones has been worked out. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 128071-75-0