Syntheses, crystallization and spectroscopic characterization of 3,5-lutidine N-oxide dehydrate was written by Merino-Garcia, Rosario;Hernandez-Anzaldo, Samuel;Reyes-Ortega, Yasmi. And the article was included in Journal of Visualized Experiments in 2018.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:
3,5-Lutidine N-oxide dehydrate was prepared from 3,5-dimethylpyridine, which reacted with H2O2, followed by crystallization The X-ray suitable crystals of 3,5-lutidine N-oxide dehydrate were possible due to the stabilization of the neg. charge in the oxygen by the presence of two water mols. where the hydrogen atoms donate pos. charge into the ring; such water mols. serve well to construct a supramol. interaction. The hydrated mols. may be possible for the alk. system that was reached by adjusting the pH to 10. Importantly, the double Me substituted ring and a reaction time of 5 h made it a more versatile method and with wider chem. applications for future ring insertions. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of 3,5-Dimethylpyridine 1-oxide