2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity was written by Micheli, Fabrizio;Cugola, Alfredo;Donati, Daniele;Missio, Andrea;Pecunioso, Angelo;Reggiani, Angelo;Tarzia, Giorgio. And the article was included in Bioorganic & Medicinal Chemistry in 1997.Application of 203794-33-6 This article mentions the following:
2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo. In the experiment, the researchers used many compounds, for example, 5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6Application of 203794-33-6).
5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 203794-33-6