Name: 2-Bromo-5-methylpyridineIn 2019 ,《Anti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines》 was published in Journal of the American Chemical Society. The article was written by Miller, David C.; Ganley, Jacob M.; Musacchio, Andrew J.; Sherwood, Trevor C.; Ewing, William R.; Knowles, Robert R.. The article contains the following contents:
A photocatalytic method for the intermol. anti-Markovnikov hydroamination of unactivated olefins with primary alkyl amines to selectively furnish secondary amine products is reported. These reactions proceed through aminium radical cation (ARC) intermediates and occur at room temperature under visible light irradiation in the presence of an iridium photocatalyst and an aryl thiol hydrogen atom donor. Despite the presence of excess olefin, high selectivities are observed for secondary over tertiary amine products, even though the secondary amines are established substrates for ARC-based olefin amination under similar conditions.2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine) was used in this study.
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: 2-Bromo-5-methylpyridine