Mitch, Charles H. et al. published their research in Journal of Medicinal Chemistry in 2011 | CAS: 3939-12-6

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Computed Properties of C6H3FN2

Discovery of Aminobenzyloxyarylamides as 榄?Opioid Receptor Selective Antagonists: Application to Preclinical Development of a 榄?Opioid Receptor Antagonist Receptor Occupancy Tracer was written by Mitch, Charles H.;Quimby, Steven J.;Diaz, Nuria;Pedregal, Concepcion;de la Torre, Marta G.;Jimenez, Alma;Shi, Qing;Canada, Emily J.;Kahl, Steven D.;Statnick, Michael A.;McKinzie, David L.;Benesh, Dana R.;Rash, Karen S.;Barth, Vanessa N.. And the article was included in Journal of Medicinal Chemistry in 2011.Computed Properties of C6H3FN2 This article mentions the following:

Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and selectivity for 榄?opioid receptors. On the basis of receptor binding assays in Chinese hamster ovary (CHO) cells expressing cloned human opioid receptors, (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide (25) had a Ki = 0.565 nM for 榄?opioid receptor binding while having a Ki = 35.8 nM for 娓?opioid receptors and a Ki = 211 nM for 鏈?opioid receptor binding. Compound 25 was also a potent antagonist of 榄?opioid receptors when tested in vitro using a [35S]-guanosine 5’O-[3-thiotriphosphate] ([35S]GTP-绾?S) functional assay in CHO cells expressing cloned human opioid receptors. Compounds were also evaluated for potential use as receptor occupancy tracers. Tracer evaluation was done in vivo, using liquid chromatog.-tandem mass spectrometry (LC/MS/MS) methods, precluding the need for radiolabeling. (S)-3-Chloro-4-(4-((2-(pyridine-3-yl)pyrrolidin-1-yl)methyl)phenoxy)benzamide (18) was found to have favorable properties for a tracer for receptor occupancy, including good specific vs. nonspecific binding and good brain uptake. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Computed Properties of C6H3FN2).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Computed Properties of C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem