Mkrtchyan, Satenik; Jakubczyk, Michal; Lanka, Suneel; Yar, Muhammad; Ayub, Khurshid; Shkoor, Mohanad; Pittelkow, Michael; Iaroshenko, Viktor O. published the artcile< Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases>, Recommanded Product: 3-(Trifluoromethyl)pyridine, the main research area is trifluoromethyl group nitro compound ytterbium catalyst mechanochem coupling transformation; amide preparation; methanimine preparation; indole preparation.
Two mild, solvent-free mechanochem. coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst were reported. This process proceeded via C-F bond activation, accompanied with utilization of Si-based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies were thoroughly studied. To the best of author knowledge, this work was the first example of mech. energy promoted transformation of the inert CF3 group into other functionalities.
Advanced Synthesis & Catalysis published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Recommanded Product: 3-(Trifluoromethyl)pyridine.