Design, synthesis, and biological activity of piperidinediamine derivatives as factor Xa inhibitor was written by Mochizuki, Akiyoshi;Nakamoto, Yumi;Naito, Hiroyuki;Uoto, Kouichi;Ohta, Toshiharu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Recommanded Product: 85838-94-4 This article mentions the following:
Cyclohexanediamine I [X = X1 = CH2] was identified as an orally bioavailable factor Xa inhibitor. Two racemic cis-piperidinediamine analogs I [X = NR, X1 = CH2; X = CH2, X1 = NR] were investigated. I [X = NR, X1 = CH2, R = CO2CMe3, H, Ac, SO2Me, CO2Et] showed higher fXa inhibitory activity, anticoagulant activity, and aqueous solubility than I [X = CH2, X1 = NR] having same substituent. I [X = NR, X1 = CH2] having sp2 nitrogen, especially amide and urea derivatives, showed potent anticoagulant activity. I [X = NR, X1 = CH2, R = OCH2OMe, NMe2] showed high oral activities in rats. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Recommanded Product: 85838-94-4).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 85838-94-4