Mohammed, Atyaf Hasan published the artcileA comparative study among effects of treatment with nifedipine, verapamil, diazepam or alpha-methyldopa on platelets count and behavior in women with preeclampsia, COA of Formula: C17H18N2O6, the main research area is preeclampsia nifedipine verapamil diazepam alpha methyldopa platelet behavior.
This study was conducted to investigate the role of platelets -count and -be- havior in the pathogenesis of mild and moderate preeclampsia (PE). Also, the effects of the specific treatment regimen in both cases of preeclampsia inves- tigated. In mild PE only nifedipine had significantly higher platelet count compared to those without treatment, while in moderate PE both verapamil and nifedipine had significantly higher platelet count compared to those without treatment. Concerning platelet response to ADP; in mild PE all drugs show an increase in response compared to those without treatment, a similar finding reported in moderate. While platelet response to collagen, in mild PE both diazepam and verapamil show increased response compared to those without treatment, in moderate PE methyldopa and verapamil show in- creased response compared to those without treatment. In conclusion, plate- lets may be involved in the pathogenesis of preeclampsia. Nifedipine and ve- rapamil produced effective enhancement of ex vivo platelets aggregation-in- duced by ADP or collagen and may evolve as antiplatelet agents that able to prevent the in vivo activation of platelets and exhaustion cycle, an action which could explain the observed effectiveness of calcium channel blockers for the prevention and treatment of preeclampsia other than diazepam or al- pha-methyldopa used in this study.
International Journal of Research in Pharmaceutical Sciences (Madurai, India) published new progress about Behavior. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, COA of Formula: C17H18N2O6.