2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 闂?8.7 闂?10闂? cm3闁荤姾娅ｅΛ纭俵闂?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ闁荤姾娅ｅΛ纭俵闂? in the liquid phase and 140.4 kJ闁荤姾娅ｅΛ纭俵闂? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 2-Chloro-4-methoxy-3-nitropyridine
1-Deaza-6-methylthiopurine ribonucleoside was written by Montgomery, John A.;Hewson, Kathleen. And the article was included in Journal of Medicinal Chemistry in 1966.Safety of 2-Chloro-4-methoxy-3-nitropyridine This article mentions the following:
7-Methylthio-3-闁?D-ribofuranosyl-3H-imidazo-[4,5-b]pyridine (I), the 1-deaza analog of the highly cytotoxic 6-methylthiopurine ribonucleoside, was prepared in two ways. In the first method, 2-amino-4-chloro-3-nitropyridine, the minor product of the amination of 2,4-dichloro-3-nitropyridine, was converted in three steps to 7-chloro-3-闁?D-ribofuranosyl-3H-imidazo [4,5-b]pyridine, which was allowed to react with NaSMe to give I. In the second method, 2,4-dichloro-3-nitropyridine was allowed to react with NaSMe to give 2-chloro-4-methylthio-3-nitropyridine, which was then converted in three steps to 7-methylthio-3H-imidazo[4,5-b]pyridine (II). Fusion of II with tetra-O-acetyl-D-ribofuranose gave predominantly the tri-O-acetyl derivative of I from which the acetyl groups were removed by treatment with methanolic ammonia. Although much less cytotoxic than 6-methylthiopurine ribonucleoside, I was cytotoxic to HEp-2 cells resistant to 6-mercaptopurine. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2Safety of 2-Chloro-4-methoxy-3-nitropyridine).
2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 闂?8.7 闂?10闂? cm3闁荤姾娅ｅΛ纭俵闂?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ闁荤姾娅ｅΛ纭俵闂? in the liquid phase and 140.4 kJ闁荤姾娅ｅΛ纭俵闂? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 2-Chloro-4-methoxy-3-nitropyridine
Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem