Mora Vargas, Jorge Andres; Ortega, Julieth Orduna; Correia dos Santos, Maite Bernardo; Metzker, Gustavo; Gomes, Eleni; Boscolo, Mauricio published the artcile< A new synthetic methodology for pyridinic sucrose esters and their antibacterial effects against Gram-positive and Gram-negative strains>, Synthetic Route of 93-60-7, the main research area is sucrose pyridinic monoester antibacterial effect gram pos neg bacteria; Acoustic cavitation; Antibacterial activity; Homogeneous catalysis; Pyridinic methyl esters; ucrose esters.
Described are the development of a new synthetic method using ultrasonic irradiation and Na methoxide as catalyst for pyridinic sucrose esters (py-SEs), derived from transesterification of sucrose with picolinic, nicotinic and isonicotinic Me esters. The reaction was optimized using a 32 x 2 exptl. design, the reaction time, temperature and sucrose:Me ester molar ratio being evaluated. The method proved to be efficient for obtaining monosubstituted esters (≥83%) with high Me ester consumption (≥79%). The monosubstituted py-SEs were isolated by semipreparative HPLC, characterized by high-resolution mass spectrometry, calorimetry, vibrational spectroscopy, and 1H and 13C NMR. The py-SEs were tested against E. coli, S. aureus, and P. aeruginosa bacteria with min. inhibitory concentration values equal or inferior to the reference drugs for both E. coli and P. aeruginosa.
Carbohydrate Research published new progress about Antibacterial agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Synthetic Route of 93-60-7.