Morales-Colon, Maria T.; See, Yi Yang; Lee, So Jeong; Scott, Peter J. H.; Bland, Douglas C.; Sanford, Melanie S. published the artcile< Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination>, Recommanded Product: 4,4′-Dichloro-2,2′-bipyridine, the main research area is aryl chloride tetramethylammonium fluoride regioselective nucleophilic aromatic fluorination; aromatic fluoride preparation.
Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations was the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alc. adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alc. substituent (R), tetramethylammonium fluoride tert-amyl alc. (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80°C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles was demonstrated.
Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Recommanded Product: 4,4′-Dichloro-2,2′-bipyridine.