Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Organic Process Research & Development called Streamlined Synthesis of the Bippyphos Family of Ligands and Cross-Coupling Applications, Author is Withbroe, Gregory J.; Singer, Robert A.; Sieser, Janice E., which mentions a compound: 894086-00-1, SMILESS is CC(P(C1=CC=NN1C2=C(C3=CC=CC=C3)N(C4=CC=CC=C4)N=C2C5=CC=CC=C5)C(C)(C)C)(C)C, Molecular C32H35N4P, HPLC of Formula: 894086-00-1.
We describe the efficient preparation of Bippyphos I [R = P(t-Bu)2] (II). The key precursor to Bippyphos, I (R = H) (III), was prepared via a one-pot bromination of diketone PhCOCH2COPh followed by alkylation with pyrazole and condensation with phenylhydrazine. Lithiation of III and trapping with di-tert-butylchlorophosphine afforded Bippyphos II. Using this approach we have prepared several derivatives of Bippyphos to probe the structure and activity relationships of this family of phosphine ligands. We also demonstrate the utility of these ligands in Pd-catalyzed amination reactions and other cross-coupling reactions.
After consulting a lot of data, we found that this compound(894086-00-1)HPLC of Formula: 894086-00-1 can be used in many types of reactions. And in most cases, this compound has more advantages.