The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-(di-tert-Butylphosphino)-1′,3′,5′-triphenyl-1’H-1,4′-bipyrazole( cas:894086-00-1 ) is researched.Computed Properties of C32H35N4P.Fox, Richard J.; Cuniere, Nicolas L.; Bakrania, Lopa; Wei, Carolyn; Strotman, Neil A.; Hay, Michael; Fanfair, Dayne; Regens, Christopher; Beutner, Gregory L.; Lawler, Michael; Lobben, Paul; Soumeillant, Maxime C.; Cohen, Benjamin; Zhu, Keming; Skliar, Dimitri; Rosner, Thorsten; Markwalter, Chester E.; Hsiao, Yi; Tran, Kristy; Eastgate, Martin D. published the article 《C-H Arylation in the Formation of a Complex Pyrrolopyridine, the Commercial Synthesis of the Potent JAK2 Inhibitor, BMS-911543》 about this compound( cas:894086-00-1 ) in Journal of Organic Chemistry. Keywords: potent JAK2 inhibitor BMS911543 preparation arylation palladium catalyst functionalization; Buchwald Hartwig coupling chemoselective reduction cyclization safety. Let’s learn more about this compound (cas:894086-00-1).
The development of an improved short and efficient com. synthesis of the JAK2 inhibitor, a complex pyrrolopyridine, BMS-911543 (I), is described. During the discovery and development of this synthesis, a Pd-catalyzed C-H functionalization was invented which enabled the rapid union of the key pyrrole and imidazole fragments. The synthesis of this complex, nitrogen-rich heterocycle was accomplished in only six steps (longest-linear sequence) from readily available materials.
Different reactions of this compound(5-(di-tert-Butylphosphino)-1′,3′,5′-triphenyl-1’H-1,4′-bipyrazole)Computed Properties of C32H35N4P require different conditions, so the reaction conditions are very important.