Moree, Wilna J. published the artcileNovel benzothiophene H1-antihistamines for the treatment of insomnia, Name: 4-Fluoropicolinonitrile, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(7), 2316-2320, database is CAplus and MEDLINE.
SAR of lead benzothiophene H1-antihistamine I (R = 2-pyridyl) was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program. Several potent and selective H1-antihistamines with a range of projected half-lives in humans were identified. Had a suitable human half-life as demonstrated in a human microdose study, but variability in pharmacokinetic profile, attributed to metabolic clearance, prevented further development of this compound I (R = 1-pyrazolyl) demonstrated lower predicted clearance in preclin. studies, and may represent a more suitable backup compound
Bioorganic & Medicinal Chemistry Letters published new progress about 847225-56-3. 847225-56-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Fluoride,Nitrile, name is 4-Fluoropicolinonitrile, and the molecular formula is C6H3FN2, Name: 4-Fluoropicolinonitrile.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem