Studies on anticoccidial agents. 12. Synthesis and anticoccidial activity of methyl-2(6)-nitro- and -3(5)-nitropyridinecarboxamides was written by Morisawa, Yasuhiro;Kataoka, Mitsuru;Sakamoto, Toshiaki;Nagahori, Hitoshi;Kitano, Noritoshi;Kusano, Kenichi. And the article was included in Journal of Medicinal Chemistry in 1978.Product Details of 65169-38-2 This article mentions the following:
Twelve methyl-2-nitro- and 9 methyl-3-nitropyridinecarboxamides were prepared and tested in vivo for anticoccidial activity against Eimeria鑱?em>tenella. Almost all the compounds were active, with optimal activity shown by 5-methyl- (I) [65169-65-5] and 6-methyl-2-nitroisonicotinamide (II) [60780-18-9], which were as potent as 2-nitroisonicotinamide. At least 1 H atom adjacent to the NO2 group is important for anticoccidial activity and a Me group adjacent to the CONH2 function sometimes enhances activity. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2Product Details of 65169-38-2).
2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 65169-38-2