《Screen of Unfocused Libraries Identified Compounds with Direct or Synergistic Antibacterial Activity》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to Mugnaini, Claudia; Sannio, Filomena; Brizzi, Antonella; Del Prete, Rosita; Simone, Tiziana; Ferraro, Teresa; De Luca, Filomena; Corelli, Federico; Docquier, Jean-Denis. Product Details of 1692-25-7 The article mentions the following:
Antibiotic resistance is an increasingly important global public health issue, as major opportunistic pathogens are evolving toward multidrug- and pan-drug resistance phenotypes. New antibiotics are thus needed to maintain our ability to treat bacterial infections. According to the WHO, carbapenem-resistant Acinetobacter, Enterobactericaeae, and Pseudomonas are the most critical targets for the development of new antibacterial drugs. An automated phenotypic screen was implemented to screen 634 synthetic compounds obtained inhouse for both their direct-acting and synergistic activity. Fourteen percent and 10% of the compounds showed growth inhibition against tested Gram-pos. and Gram-neg. bacteria, resp. The most active direct-acting compounds showed a broad-spectrum antibacterial activity, including on some multidrug-resistant clin. isolates. In addition, 47 compounds were identified for their ability to potentiate the activity of other antibiotics. Compounds of three different scaffolds (2-quinolones, phenols, and pyrazoles) showed a strong potentiation of colistin, some being able to revert colistin resistance in Acinetobacter baumannii.Pyridin-3-ylboronic acid(cas: 1692-25-7Product Details of 1692-25-7) was used in this study.
Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Product Details of 1692-25-7