Musci, Pantaleo published the artcileFlow technol. for telescoped generation, lithiation and electrophilic (C3) functionalization of highly strained 1-azabicyclo[1.1.0]butanes, SDS of cas: 91-02-1, the publication is Angewandte Chemie, International Edition (2021), 60(12), 6395-6399, database is CAplus and MEDLINE.
Strained compounds are privileged moieties in modern synthesis. In this context, 1-azabicyclo[1.1.0]butanes are appealing structural motifs that can be employed as click reagents or precursors to azetidines. We herein report the first telescoped continuous flow protocol for the generation, lithiation, and electrophilic trapping of 1-azabicyclo[1.1.0]butanes. The flow method allows for exquisite control of the reaction parameters, and the process operates at higher temperatures and safer conditions with respect to batch mode. The efficiency of this intramol. cyclization/C3-lithiation/electrophilic quenching flow sequence is documented with more than 20 examples.
Angewandte Chemie, International Edition published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, SDS of cas: 91-02-1.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem