Steric activation in prototropic reactions of pyrazine derivatives. II. The Broensted relation was written by Nagarajan, K.;Lee, T. W. S.;Perkins, R. R.;Stewart, Ross. And the article was included in Canadian Journal of Chemistry in 1986.Recommanded Product: 644-98-4 This article mentions the following:
The rate of deprotonation of the 2-Me group in 1,2,3-trimethylpyrazinium ion by RCO2–, aniline, and pyridine bases are determined in D2O. RCO2– containing bulky groups near the reaction center (e.g., o-benzoates) react faster than predicted by the Broensted equation that correlates the reactions of unhindered RCO2–. Anilines and pyridines, on the other hand, show conventional steric effects. A tentative explanation for the activation engendered by groups adjacent to the carboxylate center is based on the known effect that high concentrations of organic electrolytes have on the strengths of RCO2H but not of amines. Since ortho carboxylate ions have their relative basicities increased by an alkyl-rich environment, it is argued that the reactive Me groups of the substrate might provide such an interaction in the transition state. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Recommanded Product: 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 644-98-4