Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using 閳ョ潷ne閳?Reductases with Photoredox Catalysts was written by Nakano, Yuji;Black, Michael J.;Meichan, Andrew J.;Sandoval, Braddock A.;Chung, Megan M.;Biegasiewicz, Kyle F.;Zhu, Tianyu;Hyster, Todd K.. And the article was included in Angewandte Chemie, International Edition in 2020.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:
Flavin-dependent 閳ョ灃ne閳?reductases (EREDs) are highly selective catalysts for the asym. reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in the presence of a photoredox catalyst. Exptl. evidence suggests the reaction proceeds via a radical mechanism where the vinyl pyridine is reduced to the corresponding neutral benzylic radical in solution DFT calculations reveal this radical to be “dynamically stable”, suggesting it is sufficiently long-lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer. This reduction mechanism is distinct from the native one, highlighting the opportunity to expand the synthetic capabilities of existing enzyme platforms by exploiting new mechanistic models. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of Phenyl(pyridin-2-yl)methanone