Namera, Akira published the artcileHigh-throughput monospin extraction for quantification of cardiovascular drugs in serum coupled to high-performance liquid hromatography-mass spectrometry, Application In Synthesis of 72509-76-3, the main research area is serum pindolol carazolol high performance liquid chromatog mass spectrometry.
A novel method coupling spin column extraction with high-performance liquid chromatog.-mass spectrometry was developed for simultaneous extraction of β -blockers and calcium channel blockers from human serum. Sample loading, washing, and elution were accomplished via centrifugation of the column, in which mixed-mode monolithic silica bonded to a C18 reversed phase, and a cation-exchange phase was packed in a spin column. The serum sample (0.2 mL) pH was adjusted to 3 and the analytes adsorbed onto the column were eluted with 0.1 mL MeOH containing 2% NH3. The recov eries of the tested drugs were 76-108%. A linear curve was observed up to a concentration of 500 ng/mL of the target drugs in serum (r20 0.996). The intra-day relative standard deviations at three different concentrations were 0.6-9.6%. The limits of detection were 2 ng/mL. The proposed method was successfully applied to clin. and forensic cases.
Acta Chromatographica published new progress about Blood pressure. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Application In Synthesis of 72509-76-3.