The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Product Details of C5H3BrFN.
Narjes, Frank;Llinas, Antonio;von Berg, Stefan;Jirholt, Johan;Lever, Sarah;Pehrson, Rikard;Collins, Mia;Malmberg, Anna;Svanberg, Petter;Xue, Yafeng;Olsson, Roine I.;Malmberg, Jesper;Hughes, Glyn;Hossain, Nafizal;Grindebacke, Hanna;Leffler, Agnes;Krutroek, Nina;Baeck, Elisabeth;Ramnegaard, Marie;Lepistoe, Matti;Thunberg, Linda;Aagaard, Anna;McPheat, Jane;Hansson, Eva L.;Chen, Rongfeng;Xiong, Yao;Hansson, Thomas G. research published 《 AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2》, the research content is summarized as follows. Inverse agonists of the nuclear receptor RORC2 have been widely pursued as a potential treatment for a variety of autoimmune diseases. Author have discovered a novel series of isoindoline-based inverse agonists of the nuclear receptor RORC2, derived from recently disclosed RORC2 inverse agonist 2. Extensive structure-activity relationship (SAR) studies resulted in AZD0284 (20), which combined potent inhibition of IL-17A secretion from primary human TH17 cells with excellent metabolic stability and good PK in preclin. species. In two preclin. in vivo studies, compound 20 reduced thymocyte numbers in mice and showed dose-dependent reduction of IL-17A containing γδ-T cells and of IL-17A and IL-22 RNA in the imiquimod induced inflammation model. Based on these data and a favorable safety profile, 20 was progressed to phase 1 clin. studies.
Product Details of C5H3BrFN, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.