Electric Literature of C5H5BrN2In 2019 ,《Lewis-Acid-Catalyzed Direct Nucleophilic Substitution Reaction of Alcohols for the Functionalization of Aromatic Amines》 was published in ChemistrySelect. The article was written by Nayal, Onkar S.; Thakur, Maheshwar S.; Rana, Rohit; Upadhyay, Rahul; Maurya, Sushil K.. The article contains the following contents:
Herein, an efficient catalytic activity of tin(II) triflate for the N-alkylation of secondary anilines with alcs. for the synthesis of tertiary benzylamines I (R1 = H, 3-OMe, 4-Br, etc.; R2 = H, 4-F, 3-Me, etc.; R3 = Me, Et, i-Pr, allyl) was explored. Mechanistic studies suggest that the developed protocol follows direct nucleophilic substitution pathway instead of imine or enamine pathway. The developed method is also useful for the synthesis of secondary amines as well as late stage functionalization of naturally occurring alcs. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Electric Literature of C5H5BrN2)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Electric Literature of C5H5BrN2