Negi, Shigeto published the artcileSynthesis of (2R)-1-(4-chloro-2-pyridyl)-2-(2-pyridyl)ethylamine. A selective oxime reduction and crystallization-induced asymmetric transformation, COA of Formula: C7H6ClNO2, the main research area is pyridylethylamine preparation stereoselective crystallization; ethylamine chloropyridyl pyridyl preparation; oxime selective reduction.
Reduction of 1-(4-chloro-2-pyridyl)-2-(2-pyridyl)ethanone oxime using Zn in CF3CO2H gave the corresponding racemic pyridylethylamine I in excellent yield without reductive removal of the Cl atom. A subsequent diastereomeric crystallization of I with an optically active cis-cyclohexanecarboxylic acid derivative in the presence of a catalytic amount of 3,5-dichlorosalicylaldehyde gave the desired (R)-amine in 42% yield via a crystallization-induced asym. transformation.
Synthesis published new progress about Reduction, chemoselective. 24484-93-3 belongs to class pyridine-derivatives, name is Methyl 4-chloropicolinate, and the molecular formula is C7H6ClNO2, COA of Formula: C7H6ClNO2.