Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Computed Properties of 766-11-0.
Neumann, Theresa;Benajiba, Lina;Goering, Stefan;Stegmaier, Kimberly;Schmidt, Boris research published 《 Evaluation of Improved Glycogen Synthase Kinase-3α Inhibitors in Models of Acute Myeloid Leukemia》, the research content is summarized as follows. The challenge for glycogen synthase kinase-3 (GSK-3) inhibitor design lies in achieving high selectivity for one isoform over the other. The therapy of certain diseases, such as acute myeloid leukemia (AML), may require α-isoform specific targeting. The scorpion shaped GSK-3 inhibitors developed by the group achieved the highest GSK-3α selectivity reported so far but suffered from insufficient aqueous solubility This work presents the solubility-driven optimization of the isoform-selective inhibitors using a scorpion shaped lead. Among 15 novel compounds, compound I showed high activity against GSK-3α/β with the highest GSK-3α selectivity reported to date. Compound I was profiled for bioavailability and toxicity in a zebrafish embryo phenotype assay. Selective GSK-3α targeting in AML cell lines was achieved with compound I, resulting in a strong differentiation phenotype and colony formation impairment, confirming the potential of GSK-3α inhibition in AML therapy.
Computed Properties of 766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.