Authors Du, FY; Zhou, QF; Fu, XX; Shi, YJ; Chen, YG; Fang, WH; Yang, JY; Chen, GL in ROYAL SOC CHEMISTRY published article about SUPEROXIDE-DISMUTASE; IN-VITRO; STROKE; ISCHEMIA; MUTANT; MICE in [Du, Fangyu; Zhou, Qifan; Shi, Yajie; Chen, Yuanguang; Fang, Wuhong; Chen, Guoliang] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China; [Fu, Xiaoxiao; Yang, Jingyu] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China in 2019.0, Cited 34.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1
The development of novel neuroprotection agents is of great significance for the treatment of ischemic stroke. In this study, a series of compounds comprising 2,2-dimethylbenzopyran groups and cinnamic acid groups have been synthesized. Preferential combination principles and bioisostere that improved the neuroprotective effect of the compounds were identified for this series via biological activity assay in vitro. Meanwhile, a functional reversal group of the acrylamide amide resulted in the most active compounds. Among them, BN-07 significantly improved the morphology of neurons and obviously increased cell survival rate of primary neurons induced by oxygen glucose deprivation (OGD), superior to clinically used anti-ischemic stroke drug edaravone (Eda). Overall, our findings may provide an alternative strategy for the design of novel anti-ischemic stroke agents with more potency than Eda.
Welcome to talk about 500-22-1, If you have any questions, you can contact Du, FY; Zhou, QF; Fu, XX; Shi, YJ; Chen, YG; Fang, WH; Yang, JY; Chen, GL or send Email.. Product Details of 500-22-1
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem