Related Products of 31181-90-5, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 31181-90-5, Name is 5-Bromopicolinaldehyde, SMILES is O=CC1=NC=C(Br)C=C1, belongs to pyridine-derivatives compound. In a article, author is Genaev, Alexander M., introduce new discover of the category.
Unusual temperature-sensitive protonation behaviour of 4-(dimethylamino)pyridine
Stimuli-responsive and, in particular, temperature-responsive smart materials have recently gained much attention in a variety of applications. On the other hand, 4-(dimethylamino)pyridine (DMAP) and related structures are widely used as nucleophilic catalysts and also as specific parts of rationally designed molecules, where reversible reactions of the pyridinic nitrogen with electrophiles are involved. In our study, we have found an unexpectedly significant impact of temperature on the protonation degree of DMAP derivatives, especially in the case of protonation of the 4-(dimethylamino)-1-(2,3,5,6-tetrafluoropyridin-4-yl)pyridinium cation, derived from the reaction of DMAP with pentafluoropyridine. Thus, when dissolved in the TfOH-SO2ClF-CD2Cl2 acid system at 30 degrees C, this cation underwent a slight (<7%) protonation on the dimethylamino group, while the temperature decrease to -70 degrees C resulted in its complete protonation. Notably, such a scale of this phenomenon has never been observed before for other weak nucleophiles, being many times lower at the same change of temperature. The mechanistic aspects of these intriguing results are discussed. Related Products of 31181-90-5, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 31181-90-5.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem