In an article, author is El-sayed, Hassan A., once mentioned the application of 325855-74-1, Quality Control of 5-Chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3′-bipyridine] 1′-oxide, Name is 5-Chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-[2,3′-bipyridine] 1′-oxide, molecular formula is C18H15ClN2O3S, molecular weight is 374.84, MDL number is MFCD30609556, category is pyridine-derivatives. Now introduce a scientific discovery about this category.
An Efficient and Green Synthesis of Highly Substituted N-Amino-2-oxo-nicotinonitriles and Their Sulfonamide Derivatives under Ultrasonic and Microwave Irradiation
An efficient and facile approach has been described for the synthesis of a new series of 1-amino-2-oxo-nicotinonitriles and their sulfonamides under microwave and ultrasonic irradiation. The desired compounds 4 a-l were obtained via condensation of p-chlorobenzaldehyde, aryl or heteroaryl methyl ketone and cyanoacetohydrazide in the presence of catalytic piperidine under three synthetic methodologies (namely, conventional method, ultrasonic and microwave irradiation), the best results (short reaction times, pure products, high yield) were obtained by ultrasonic irradiation. Sulfonamides 5 a-f resulted via reaction of amines 4 a-e and 4 j with benzene sulfonyl chloride in the presence of pyridine. The synthesized compounds give no significant results when investigated against Gm (+ve) and Gm (-ve) bacteria, and fungi strains.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem