Synthesis and cytotoxicity of novel 1-arylindolizines and 1-arylpyrrolo[2,1-a]isoquinolines was written by Nevskaya, Alisa A.;Miftyakhova, Almira R.;Anikina, Lada V.;Borisova, Tatiana N.;Varlamov, Aleksey V.;Voskressensky, Leonid G.. And the article was included in Tetrahedron Letters in 2021.Reference of 91-02-1 This article mentions the following:
An efficient approach to the synthesis of indolizines and pyrrolo[2,1-a]isoquinolines based on a domino reaction was described. The reactivity of the derivatives and the structure-activity anal. are carried out in a number of the obtained compounds A hit was found showing high cytotoxicity on tumor cells whose cytotoxic effect was comparable to that of the known topoisomerase I inhibitor camptothecin. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Reference of 91-02-1).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Reference of 91-02-1