Related Products of 888721-65-1 ,Some common heterocyclic compound, 888721-65-1, molecular formula is C13H10FNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 48 N-(4-(6-Amino-1-methyl-1H-indazol-5-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide methanesulfonate To a 10 mL screw-cap vial is added 5-(4-amino-2-fluorophenoxy)-N-benzhydryl-1-methyl-1H-indazol-6-amine (91 mg, 208 mumol), 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid (66.7 mg, 269.78 mumol), EDCI (90.9 mg, 466.9 mumol) and HOBt (47.7 mg, 311.3 mumol) followed by DMF (2 mL, 25.9 mmol). To the mixture is added DIPEA (90.5 muL, 518.8 mumol) and the mixture is stirred at RT for 12 hours. Additional EDCI (50 mg), HOBt (25 mg), DIPEA (0.02 mL), and 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid (40 mg) are added and the mixture is stirred for an additional 24 hours. The reaction is diluted into EtOAc (100 mL) and washed with saturated aqueous sodium chloride (3*25 mL). The combined aqueous solution is extracted with EtOAc (1*25 mL). The combined organic (100 mL) and washed with saturated aqueous sodium chloride (3*25 mL). The combined aqueous solution is extracted with EtOAc (1*25 mL). The combined organic solution is dried over Na2SO4, filtered, and concentrated to dryness. The residue is purified on a silica gel column eluding with DCM (A) and a 10% MeOH in DCM solution (B), gradient from 100% (A) to 90%(A): 10%(B) over 60 min to give a clear wax material as the desired product (114 mg, 82% yield). MS (m/z) 667.8 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 888721-65-1, 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LI, Tiechao; POBANZ, Mark Andrew; SHIH, Chuan; WU, Zhipei; YANG, Wei Jennifer; ZHONG, Boyu; US2010/22529; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem