Reference of 67310-56-9 ,Some common heterocyclic compound, 67310-56-9, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
f) 1-(5-Methoxymethoxy-pyridin-2-yl)-ethanoneNaH was added to a solution of 1 g (7.29 mmol) 1-(5-hydroxy-pyridin-2-yl)-ethanone (Anichem) in 15 ml DMF at 0 C. After stirring this mixture for 1 h, 0.78 ml (8.75 mmol) MOMCl was added at 0 C. Then the reaction mixture was stirred at room temperature for 2 h. The reaction mixture was poured on water and extracted 2 times with EtOAc. The combinded organic layers were washed with water and brine, dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by chromatography on silicagel (EtOAc, heptane) to yield 1.12 g of the pure title compound as an oil. LCMS (method L): tR=0.66 min, M+H=182.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 67310-56-9, 1-(5-Hydroxypyridin-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; US2011/3786; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem