New downstream synthetic route of 1074-98-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-98-2, 3-Methyl-4-nitropyridine 1-oxide, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1074-98-2, name is 3-Methyl-4-nitropyridine 1-oxide, molecular formula is C6H6N2O3, molecular weight is 154.13, as common compound, the synthetic route is as follows.HPLC of Formula: C6H6N2O3

[0334] 3-Methyl-4-nitropyridine 1-oxide (24.1a, 12.0 g, 0.07786 mol) was dissolved in acetyl chloride (60.00 mL). The reaction was heated to reflux for 2 hours. After cooling the reaction was poured onto ice and was basified with anhydrous sodium carbonate and extracted with chloroform. The extract was dried with potassium carbonate and filtered. The chloroform was evaporated off to yield the desired product in high purity. (85% yield) The MP was taken and found to be at 124 C, which matches literature references.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-98-2, 3-Methyl-4-nitropyridine 1-oxide, and friends who are interested can also refer to it.

Reference:
Patent; ADOLOR CORPORATION; WO2008/63625; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem