New downstream synthetic route of 1173897-86-3

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1173897-86-3, 5-Bromo-6-methylpicolinonitrile, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1173897-86-3, name is 5-Bromo-6-methylpicolinonitrile, molecular formula is C7H5BrN2, molecular weight is 197.032, as common compound, the synthetic route is as follows.Application In Synthesis of 5-Bromo-6-methylpicolinonitrile

A suspension of 5-bromo-6-methylpyridine-2-carbonitrile (CAS 1173897-86-3, 0.195 g, 0.990 mmol), PdCl2(dppf) (0.072 g, 0.099 mmol), Z>w(pinocolato)diboron (0.352g, 1.386 mmol) and potassium acetate (0.194 g, 1.979 mmol) in dry DMSO (1.979 mL) was degassed (vacuum / nitrogen cycles) and heated in a sealed tube at 90 C for 4 h. The mixture was diluted with EtOAc, washed sequentially with water and brine, dried (phase separator) and concentrated in vacuo. The resulting residue was purified by flash chromatography (0-30% EtOAc in petrol on Si02) to afford the title compound. MS ES+: 245

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1173897-86-3, 5-Bromo-6-methylpicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; AHMED, Saleh; BARKER, Gregory; CANNING, Hannah; DAVENPORT, Richard; HARRISON, David; JENKINS, Kerry; LIVERMORE, David; WRIGHT, Susanne; KINSELLA, Natasha; (259 pag.)WO2016/148306; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem