Synthetic Route of 1211530-54-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1211530-54-9, name is 5-(Bromomethyl)nicotinonitrile, molecular formula is C7H5BrN2, molecular weight is 197.03, as common compound, the synthetic route is as follows.
To a solution of 5-chloro-2-hydroxy-4-(4-phenylindan-1-yl)oxy-benzaldehyde (100 mg, 0.274 mmol) in DMF (5 mL) was added 5-(bromomethyl)pyridine-3-carbonitrile (108 mg, 0.549 mmol) followed by Cs2CO3 (178 mg, 0.549 mmol). The resulting suspension was then stirred at 65 C. for 2 h. The reaction mixture was diluted with EtOAc (20 mL),washed with water (20 mL), dried (MgSO4), concentrated in vacuo. The crude residue was purified by flash chromatography (SiO2, 80% EtOAc in hexanes) to obtain 5-[[4-chloro-2-formyl-5-(4-phenylindan-1-yl)oxy-phenoxy]methyl]pyridine-3-carbonitrile. MS: (ES) m/z calculated for C29H22ClN2O3[M+H]+ 481.1. found 481.3.
Statistics shows that 1211530-54-9 is playing an increasingly important role. we look forward to future research findings about 5-(Bromomethyl)nicotinonitrile.
Reference:
Patent; CHEMOCENTRYX, INC.; LANGE, Christopher; MALATHONG, Viengkham; McMURTRIE, Darren J.; PUNNA, Sreenivas; SINGH, Rajinder; YANG, Ju; ZHANG, Penglie; (210 pag.)US2018/8554; (2018); A1;,
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