Related Products of 1211532-15-8 ,Some common heterocyclic compound, 1211532-15-8, molecular formula is C8H6F3NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Intermediate 37: Synthesis of 6-hydroxy-5-(trifluoromethyl)nicotinic acid; To a solution of TMSCI (0.75 ml_, 5.88 mmol) in dry MeCN is added potassium iodide (0.98 g, 5.88 mmol). The crude is stirred at room temperature for 10 mins. To this crude is added a solution of 6-methoxy-5-(trifluoromethyl)nicotinic acid (1 .3 g, 5.88 mmol) in MeCN (2 ml_). The crude is stirred at 80 deg C for 4 hrs and room temperature for overnight. The crude is concentrated and diluted in ether and 1 N HCI. The organic layer is washed with water, brine, dried over MgSO4, filtered and concentrated. The crude is purified via RP-HPLC (SunFire C18, H2O(O. I 0ZoTFA)ZCH3CN) to give 6-hydroxy-5-(trifluoromethyl)nicotinic acid (377 mg). HPLC retention time = 0.85 minutes (condition B); MS 208.0 (M+1 ). 1 H NMR (400 MHz, CD3OD) delta ppm 8.34 (s, 2 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1211532-15-8, 6-Methoxy-5-(trifluoromethyl)nicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; COPPOLA, Gary Mark; IWAKI, Yuki; KARKI, Rajeshri Ganesh; KAWANAMI, Toshio; KSANDER, Gary Michael; MOGI, Muneto; SUN, Robert; WO2010/136474; (2010); A2;,
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