Related Products of 14254-57-0 ,Some common heterocyclic compound, 14254-57-0, molecular formula is C6H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of fe/7-butyl 5-(2-(3-aminophenyl)-7-methoxy-6-(3- morpholinopropoxy)quinazolin-4-ylamino)-1H-indazole-1-carboxylate (0.064g, 0.102 mmol) in CH2Cl2 (4mL), DIEA (0.041g, 0.32mmol) and isonicotinoyl chloride (0.022g, 0.123 mmol) were added were added. The resulting mixture was stirred at RT for 2.5h. The volatiles were removed in vacua and the residue was taken up in CH2CIj (15 mL), washed with NaHCOi solution, water and brine, dried (Na2SO4) and filtered.[0379] The residue was taken up in CH2Cl2 (3 mL) and TFA (3 mL) was added. The mixture was stirred at RT for 2.5 h. The volatiles were removed in vacuo and the residue was washed with Et2O and hexane. The solid was dried under vacuum to give the desired product N-(3-(4-( 1 H-indazol-5-ylamino)-7-methoxy-6-(3-rnorpholinopropoxy)quinazolin -2-yl)phenyl)isonicotinamide (0.073g, 0.098mmol, 96%). MS 63 1 .3 (M+ 1 ). HPLC retention time 3.94 mins
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14254-57-0, its application will become more common.
Reference:
Patent; SURFACE LOGIX, INC.; SWEETNAM, Paul; BARTOLOZZI, Alessandra; CAMPBELL, Anthony; COLE, Bridget; FOUDOULAKIS, Hope; KIRK, Brian; SESHADRI, Hemalatha; RAM, Siya; WO2010/104851; (2010); A1;,
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