Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide. This compound has unique chemical properties. The synthetic route is as follows. 145100-50-1
(101c) Triethylamine (115 mL, 7.8 eq) was added to a suspension of 2-[N,N-bis(trifluoromethylsulfonyl)amino]pyridine (14.95 g, 3 eq) and the phenol from reaction 101b (3.53 g, 13.88 mmol) in CH2Cl2 (50 mL). After stirring at room temperature for 2 h, the mixture was concentrated and re-dissolved in EtOAc (200 mL), washed with 1 N HCl (2¡Á1100 mL), brine (20 mL), dried (MgSO4) and concentrated. Silica gel chromatography (30% EtOAc-hexanes) gave the desired triflate (3.97 g, 74%).
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Reference:
Patent; Bristol-Myers Squibb Company; US2007/185056; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem