Related Products of 148493-37-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 148493-37-2, name is 2,6-Dichloro-3-iodopyridine, molecular formula is C5H2Cl2IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Production Example 962- (4-{2- [6- (4-acetylpiperazin-l-yl) -3- (trifluoromethyl)pyridin-2-yl] ethyl }phenyl) acetohydrazide dihydrochloride step 1 [0304] [0305]Potassium fluoride (2.24 g, 38.5 mmol) and copper (I) iodide (7.33 g, 38.5 mmol) were weighed in a flask, and the mixture was heated with a gas burner while gently shaking under high vacuum until the content becomes a pale-yellow green. After cooling to room temperature, anhydrous N, N- dimethylformamide (50 ml) , anhydrous tetrahydrofuran (10 ml) and trimethyl (trifluoromethyl) silane (5.5 ml, 35 mmol) were added. The mixture was heated to 5O0C, and stirred for 21 hrs. A mixed solution of 2, beta-dichloro-3-iodopyridine (9.59 g, 35.0 mmol) in anhydrous N, N-dimethyIformamide (10 ml)- anhydrous tetrahydrofuran (20 ml) was added dropwise to the above- mentioned reaction mixture at 5O0C. After stirring at 50C for 21 hrs, trimethyl (trifluoromethyl) silane (0.55 ml, 3.5 mmol) was added, and the mixture was stirred for 24 hrs. The reaction mixture was cooled to room temperature, poured into 12% aqueous ammonia, and the mixture was extracted 3 times with diethyl ether. The combined organic layer was washed successively with 12% aqueous ammonia, IM hydrochloric acid,
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 148493-37-2, 2,6-Dichloro-3-iodopyridine.
Reference:
Patent; R-tech Ueno, Ltd.; WO2009/145360; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem