New downstream synthetic route of 1620-72-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1620-72-0, 2-Methyl-6-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1620-72-0, 2-Methyl-6-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H6F3N, blongs to pyridine-derivatives compound. HPLC of Formula: C7H6F3N

2-methyl-6-(trifluoromethyl)pyridine (100 mg, 0.620 mmol) was dissolved in CCl4 (3 mL), and N-bromosuccinimide (NBS) (110 mg, 0.620 mmol) and 1,1′-azobis(cyclohexanecarbonitrile) (VAZO, 8 mg, 0.031 mmol) were added thereto, followed by heating and stirring at 90 C. for 15 hrs. The reaction solution was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by MPLC (Hex/EA=5:1) to obtain the title compound as white solid (42.5 mg, yield: 28.4%). 1H NMR (300 MHz, CDCl3) delta 4.60 (2H, s), 7.61 (1H, d), 7.68 (1H, d), 7.90 (1H, t)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1620-72-0, 2-Methyl-6-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; SK CHEMICALS CO., LTD.; Kim, Seon-Mi; Kim, Jae-Sun; Lee, Minhee; Lee, So-young; Lee, Bong-Yong; Shin, Young Ah; Park, Euisun; Lee, Jung A; Han, Min-Young; Ahn, Jaeseung; Yoo, Taekyung; Kim, Hun-Taek; US2015/166558; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem