Electric Literature of 16727-47-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 16727-47-2, name is 2,6-Bis(benzyloxy)-3-bromopyridine. This compound has unique chemical properties. The synthetic route is as follows.
Preparation of 25-2 To a stirred solution of 24-2 (455mg, 1.22 mmol) in toluene was added 25-1 (100 mg, 860.86 mumol) and K3PO4.H2O (494 mg, 215 mumol) and the resulting mixture was degassed with Argon for 10 minutes. To this were added CuI (0.05 mg, 0.26 mumol) and trans-N,N?- dimethylcyclohexane-1,2-diamine (17 mg, 120 mumol) and heated to 100C for 16 hours to produce 25-2. Reaction mixture was cooled to room temperature and filtered through a short bed of celite. The filtrate was diluted with Ethyl acetate, washed with water and brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. Crude mass was purified doing column chromatography (silica, gradient: 0-20% Ethyl acetate in Hexane) to afford 25-2 (200 mg, 514 mumol, 60%) as sticky off-white solid. LC MS: ES+ 390.2.
According to the analysis of related databases, 16727-47-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; C4 THERAPEUTICS, INC.; PHILLIPS, Andrew, J.; NASVESCHUK, Chris, G.; HENDERSON, James, A.; LIANG, Yanke; CHEN, Chi-li; DUPLESSIS, Martin; HE, Minsheng; LAZARSKI, Kiel; (980 pag.)WO2017/197051; (2017); A1;,
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