Reference of 169205-95-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 169205-95-2, name is 2-(Methylthio)oxazolo[4,5-b]pyridine. A new synthetic method of this compound is introduced below.
Example 17 Production of 6-(oxazolo[4,5-b]pyridin-2-ylamino)-N-(2,6-diisopropylphenyl)hexanamide 2-Methylthiooxazolo[4,5-b]pyridine (65.0 mg, 0.39 mmol) and 6-amino-N-(2,6-diisopropylphenyl)hexanamide (114 mg, 0.39 mmol) were mixed together and stirred at 90 C. for 2 hours. The reaction mixture was purified by preparative thin layer chromatography (elution solvents: hexane_acetone=5:3). The resulting crude crystal was recrystallized from dichloromethane-ether-hexane, to recover the objective compound as a colorless needle-like crystal. Melting Point: 152-153 C. IR (KBr) cm-1: 3416, 2964, 1656, 1571, 1413. 1H-NMR (d6-DMSO) delta: 1.11 (12H, d, J=6.8 Hz), 1.43-1.57 (2H, m), 1.64-1.77 (4H, m), 2.35 (2H, t, J=7.3 Hz), 3.08 (2H, sept, J=6.8 Hz), 3.38 (2H, dd, J=12.9, 6.8 Hz), 6.89 (1H, dd, J=7.8, 5.1 Hz), 7.09 (1H, d, J=8.3 Hz), 7.09 (1H, d, J=7.1 Hz), 7.19 (1H, dd, J=8.3, 7.1 Hz), 7.53 (1H, dd, J=7.8, 1.5 Hz), 7.87 (1H, br s), 8.06 (1H, dd, J=5.1, 1.5 Hz), 8.65 (1H, br s). EIMS m/z (relative intensity): 408 (M+, 100). Elementary Analysis: C24H32N4O2 Required: C, 70.56; H, 7.89; N, 13.71. Found: C, 70.70; H, 7.87; N, 13.51.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,169205-95-2, its application will become more common.
Reference:
Patent; Kowa Company, Ltd.; US6362208; (2002); B1;,
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