New downstream synthetic route of 19798-77-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 19798-77-7, 4-Amino-3-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Amino-3-chloropyridine, blongs to pyridine-derivatives compound. name: 4-Amino-3-chloropyridine

In a second step, the first step of the product 2- [1- (2-methylbutyl) -1H-indol-3-yl] acetic acid was added to dichloromethane(20 mL) and stirred at room temperature. EDCI (1.27 g) (10g) wasstirred for 10 min, and the organic phase was added to saturated brine(10 mL), and the mixture was stirred at room temperature for 3 h.The organic phase was separated by column chromatography and eluted with ethyl acetate-petroleum ether (1: 3) to giveN- (3-chloropyridin-4-yl) -2- [1- (Methylbutyl) -1H-indol-3-yl] acetamide (1.4 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Chen Qing; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107174581; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem