Reference of 13228-40-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13228-40-5, name is 2-(2-Pyridyl)indole. A new synthetic method of this compound is introduced below.
Step 3: To a solution of 16 (1.6 g, 8.24 [MMOL) IN ACOH] (30 ml) at 80 [C] was added 4-piperidone hydrochloride (3.7 g, 23.9 [MMOL)] and [H3PO4] (10 [ML).] The reaction was stirred at this temperature for 72 h and at [100] C for 24 h. The reaction was cooled to RT and poured into [ICE/NH40H] and extracted with EtOAc. The combined organic layers were washed with water and brine, dried [(NA2SO4)] and concentrated. The residue was purified on a flash column (20% EtOAc in hexane to 10% CH30H/NH3 in [CH2CI2)] to give 17 (0.5 g, 44% based on recovered starting material). MS (M+H) [=] 276.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13228-40-5, its application will become more common.
Reference:
Patent; SCHERING CORPORATION; WO2004/831; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem