Reference of 100202-78-6 ,Some common heterocyclic compound, 100202-78-6, molecular formula is C6H5BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 3-methylpyrazole-4-boronic acid pinacol ester (1.51 g, 7.26 mmol) in DMF (40 mL) was added 2-Methyl) -6-fluoropyridine (2.1 g, 11 mmol), Cs2CO3 (8.3 g, 25 mmol) and KI (0.6 g, 4 mmol) were added and then reacted at 70 C overnight. The reaction solution was concentrated under reduced pressure to remove DMF, water (40 mL) was added thereto and extracted with methylene chloride (50 mL × 3). The organic phase was washed with anhydrousNa2SO4 and the concentrated crude product was purified by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 4/1) to give1.5 g of a yellow oil, yield: 65%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100202-78-6, 2-(Bromomethyl)-6-fluoropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Zhou Youbo; Yang Tiping; He Wei; Zhang Yingjun; Zheng Changchun; (103 pag.)CN106749268; (2017); A;,
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