New downstream synthetic route of 2-Fluoro-4-iodo-5-picoline

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153034-94-7, 2-Fluoro-4-iodo-5-picoline.

Electric Literature of 153034-94-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-94-7, name is 2-Fluoro-4-iodo-5-picoline. This compound has unique chemical properties. The synthetic route is as follows.

Preparation 3; 5-Bromomethyl-2-fluoro-4-iodo-pyridine; In a flask, combine 2-fluoro-4-iodo-picoline (10.0 g, 42.19 mmol), N- bromosuccinimide (9.76 g, 54.85 mmol), 2, 2′-azobisisobutyronitrile (3.46 g, 21.10 mmol) and dry CCl4 (100 mL). Heat at 70 0C under nitrogen for 16 hours. Cool to room temperature. Dilute with dichloromethane and wash with water and saturated aqueous sodium chloride. Separate the layers and dry the organic layer over magnesium sulfate. Concentrate in vacuo to give crude product. Purify by column chromatography (1 % to 15 % ethyl acetate in hexane) to afford the title compound (8.27 g, 62 %). MS (EI) m/z 315M+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153034-94-7, 2-Fluoro-4-iodo-5-picoline.

Reference:
Patent; ELI LILLY AND COMPANY; WO2008/76705; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem