With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5975-12-2, name is 2,4-Dichloro-3-nitropyridine, molecular formula is C5H2Cl2N2O2, molecular weight is 192.9876, as common compound, the synthetic route is as follows.category: pyridine-derivatives
Example 23Preparation of 7-(4-amino-2-(6-chlorobenzo[d][1,3]dioxol-5-ylthio)-1H-imidazo[4,5-c]pyridin-1-yl)-N-hydroxyheptanamide (Compound 34)Step 23a. 2-Chloro-N-(4-methoxybenzyl)-3-nitropyridin-4-amine (Compound 602); To a stirred solution of compound 601 (1 g, 5.18 mmol) in DMF (8.6 mL) was added (4-methoxyphenyl)methanamine (0.71 g 5.18 mmol) and triethylamine (0.644 mL). The reaction mixture was stirred at room temperature for 2 h. The mixture was evaporated to remove DMF and purified by column chromatography on silica gel (EtOAc/petroleum at 10:1) to obtain 602 as a yellow solid (1.32 g, 87%): LCMS: 294 [M+1]+; 1H NMR (DMSO-d6): delta 3.72 (s, 3H), 4.40 (d, 2H, J=6.3 Hz), 6.81 (d, 1H, J=5.7 Hz), 6.91 (d, 2H, J=9.0 Hz), 7.25 (d, 2H, J=8.4 Hz), 7.95 (d, 1H, J=5.4 Hz), 8.02 (t, 1H, J=5.7 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5975-12-2, 2,4-Dichloro-3-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Qian, Changgeng; Cai, Xiong; Gould, Stephen; Zhai, Haixiao; US2008/234297; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem