Synthetic Route of 1604-14-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1604-14-4, name is 2,6-Dichloro-isonicotinic acid ethyl ester, molecular formula is C8H7Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 7E (2,6-dichloropyridin-4-yl)methanol To a solution of EXAMPLE 7D (3.1 g, 14.2 mmol) in ethanol (100 mL) at 0C was added sodium triacetoxyborohydride (2.7 g, 71.1 mmol) in portions and the mixture was heated at 80C for 3 hours. The mixture was concentrated and the residue was diluted with water (20 mL). I N Hydrochloric acid was added to quench excess sodiumtriacetoxyborohydride and then the mixture was neutralized with saturated aqueous sodium carbonate. The mixture was extracted with dichloromethane (3 x 20 mL) and the combined organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was recrystallized from methanol to give the title compound. MS: 178 (M + H+).
According to the analysis of related databases, 1604-14-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
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