Reference of 89282-03-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 89282-03-1 as follows.
A reaction mixture containing 3-ethynyl-5-nitro-1 -trityl-1 H-indazole (215 mg, 0.5 mmol), 3-iodo-pyridin-4-ol (132 mg, 0.6 mmol), copper (I) iodide (4.5 mg, 0.025 mmol), PdCI2(PPh3)2 and triethylamine (120 mg, 1.2 mmol) in DMF (3 ml_) was heated at 100 C overnight under argon. After the completion of reaction (shown by TLC), ethyl acetate (50 mL)was added and the reaction mixture was added to water. The organic layer was collected, washed with water, brine and concentrated under vacuum. After purification using silica (7% methanol in dichloromethane), the desired product was obtained (210 mg, 0.4 mmol ) in 80% yield.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89282-03-1, its application will become more common.
Reference:
Patent; SCHERING CORPORATION; WO2008/153858; (2008); A1;,
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