With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18368-73-5, name is 3-Methyl-2-nitropyridine, molecular formula is C6H6N2O2, molecular weight is 138.12, as common compound, the synthetic route is as follows.name: 3-Methyl-2-nitropyridine
2-nitro 2-methylpyridine (4.2 g, 30.66 mmol) was dissolved in 100 mL of carbon tetrachloride,N-bromosuccinimide (5.5 g, 30.66 mmol) was added,Add the catalyst amount of the photoinitiator dibenzoyl peroxide, heat up to 100 C and reflux for 48 h.The reaction solution was returned to room temperature, the solvent was removed by distillation under reduced pressure, 50 mL of ice water was added,Extracted with ethyl acetate (40 mL X3). The extract was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated to a crude product. The crude product was purified by silica gel column chromatography (ethyl acetateEster: petroleum ether = 1: 10) 3-Bromoethyl-2-nitropyridine (2.9 g, 44.14%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,18368-73-5, 3-Methyl-2-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Jiao Tong University; Fu Lei; Xie Dongsheng; Qiao Yixue; Liu Wenlu; Yu Jihao; (24 pag.)CN106749045; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem