Electric Literature of 86649-57-2, Adding some certain compound to certain chemical reactions, such as: 86649-57-2, name is 3-Pyridyloxyacetic acid,molecular formula is C7H7NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 86649-57-2.
Add slowly 1-propanephosphonic acid cyclic anhydride (122.30 g, 100.00 mL,192.18 mmol) to a solution of 2-hydroxy-2-methyl-N-( 1,2,3 ,4-tetrahydroisoquinolin-6-yl)propane-1-sulfonamide hydrochloride (46.90 g, 146.18 mmol), 2-(3-pyridyloxy)acetic acid (27.00 g, 176.31 mmol), dimethylformamide (708.98 g, 750.00 mL, 9.70 mol), triethylamine (59.53 g, 82.00 mL, 588.31 mmol) at 0 C. Allow the reaction to warm slowly to room temperature and stir overnight. Add saturated aqueous sodium sulfate solution (500 mL) and water (500 mL). Extract with dichloromethane (3 xl L), combine the organic layers, dry over anhydrous sodium sulfate, filter and concentrate underreduced pressure. Purify by silica gel chromatography eluting with a mobile phase of dichloromethane/methanol (0% to 10% methanol over 90 minutes). Combine fractions containing a mixture of peaks from previous purification and purify by silica gel chromatography eluting with a mobile phase of dichloromethane/methanol (0% to 10% methanol over 45 minutes) to afford the title compound (8.00 g, 19.05 mmol).Combine the two fractions to afford the title compound (38.00 g, 90.58 mmol). MS (m/z): 420 (M+1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 86649-57-2, 3-Pyridyloxyacetic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ELI LILLY AND COMPANY; BURKHOLDER, Timothy Paul; DEL PRADO, Miriam Filadelfa; FERNANDEZ, Maria Carmen; HEINZ II, Lawrence Joseph; PRIETO, Lourdes; ZHAO, Genshi; WO2015/54060; (2015); A1;,
Pyridine – Wikipedia,
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