Application of 934180-48-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.934180-48-0, name is 4-Chloro-2-methoxy-3-nitropyridine, molecular formula is C6H5ClN2O3, molecular weight is 188.57, as common compound, the synthetic route is as follows.
Tin(ll)chloride dihydrate (12 g, 53.19 mmol) was added to a solution of 4-chloro-2- methoxy-3-nitropyridine (2 g, 10.64 mmol) in ethyl acetate (30 ml.) and the resultant suspension heated at 70 C with stirring for 2 h. The reaction mixture was cooled to ambient temperature, the pH adjusted to pH 9-10 by addition of saturated sodium carbonate (aq.) and extracted with ethyl acetate (3 x 10OmL). The combined extracts were dried (MgSO4) and concentrated in vacuo to give the crude product. Purification by chromatography on silica gel with EtOAc:heptane (1 :9, v/v) as eluent afforded the product as a colourless oil (1.28 g, 76 %).Data for 3-amino-4-chloro-2-methoxypyridine: MS (ESI) m/z: 159/161 ([M+H]+).
The chemical industry reduces the impact on the environment during synthesis 934180-48-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; N.V. ORGANON; WO2007/39563; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem